日日夜夜影院在线播放-日日夜夜天天操-日日夜夜噜噜-日日夜夜撸 在线影院-处xxxx.88-处88XXX

首頁 >> 產品展示 >> 抗體 >> chromotek代理商 >> Chromotek/F2H®-Kit Androgen Receptor

Chromotek/F2H®-Kit Androgen Receptor

簡要描述:Chromotek/F2H®-Kit Androgen Receptor Analyze modulators of the human Androgen Receptor
  Detect early steps of Androgen Receptor activation

  • 產品型號:
  • 廠商性質:經銷商
  • 更新時間:2018-01-22
  • 訪  問  量:1677
詳細資料

Chromotek/F2H®-Kit Androgen Receptor

 螞蟻淘介紹:

螞蟻淘,【正品極速】生物醫(yī)學科研用品輕松購

螞蟻淘(ebiomall)是一家生命科學領域的垂直電商平臺,公司專注生物醫(yī)學科研用品的  導購和品牌推廣,為海外廠方與國內代理經銷商搭建跨境貿易系統(tǒng)和交流平臺。

    產品齊全,200+分類,1000+品牌,500+產品信息。100%正品,專業(yè)售后,到貨快,在線下單, 簡單輕松,節(jié)省科學家寶貴的科研時間。

借助互聯(lián)網平等而開放的力量,矢志實現(xiàn)生命科學領域的信息同步,我們相信一群充滿夢想的人,可以憑借著專業(yè)與執(zhí)著,讓你的購物更輕松!

Chromotek/F2H®-Kit Androgen Receptor

  Analyze modulators of the human Androgen Receptor

  Detect early steps of Androgen Receptor activation

  Visualized in live mammalian cells

  Real-time agonists and antagonists screening

  Convenient readout using an epi-fluorescence microscope

  The human Androgen receptor (AR) is an important target for developing drug therapies combating prostate cancer. The very early event in AR activation, namely the intramolecular interaction between the N- and C-terminus of AR, can now be analyzed with the ChromoTek Fluorescent-Two Hybrid (F2H®) AR: wild-type (wt), as well as several mutant AR forms can be investigated.

Chromotek/F2H®-Kit Androgen Receptor  

Assay principle:

  AR is expressed as two separate domains: AR-LBD (ligand binding domain), comprising the AR’s C-terminus, either wt or mut, fused to GFP: AR-LBD-GFP

  AR-NTD (N-terminal domain), comprising the AR’s N-terminus, fused to RFP: AR-NTD-RFP

  F2H®-BHK cells express components of the protein-protein interaction platform, which recruits GFP-tagged AR-LBD to a specific location in the nucleus

  AR-LBD-GFP and AR-NTD-RFP constructs are co-transfected into the F2H®-BHK cells

  AR-LBD-GFP forms a bright green spot at the specific location in the nuclei whereas AR-NTD-RFP is diffusely distributed in the nucleus

  Upon stimulation by an agonist (e.g. DHT), immobilized AR-LBD-GFP undergoes a conformation change and recruits AR-NTD-RFP: AR-NTD-RFP forms a bright red spot superimposed with the green spot.

  Results:

  Green spot is present, red spot is absent => assay works: no interaction

  Green spot is present, red spot is present at the same location => assay works: interaction

  

 

  Figure: AR-LBD-GFP (top left) forms bright green spots at the genetic Platform in nuclei of F2H-BHK cells. Before addition of DHT, AR-NTD-RFP (bottom left) is dispersed in the nuclei. Upon 20 min incubation with 10nM DHT, the red spots appear (bottom right, arrows) at the location of the green spots, indicating induction of the interaction between AR-LBD and AR-NTD.

  Reversible Screening:

  The F2H AR assay is fully reversible: the AR wt interaction can be induced by an agonist (e.g. 0.25nM DHT) and then subsequently disrupted by addition of a potent antagonist (e.g. 10µM bicalutamide).

如果你對Chromotek/F2H®-Kit Androgen Receptor感興趣,想了解更詳細的產品信息,填寫下表直接與廠家聯(lián)系:

留言框

  • 產品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細地址:

  • 補充說明:

  • 驗證碼:

    請輸入計算結果(填寫阿拉伯數(shù)字),如:三加四=7

蘇州螞蟻淘生物科技有限公司(www.hzxcvlv.cn)主營產品:海外生命科學試劑儀器代購

總訪問量:263598  管理登陸  技術支持:化工儀器網  sitemap.xml

版權所有 © 2025 蘇州螞蟻淘生物科技有限公司  ICP備案號:蘇ICP備17049038號-2
在線留言 聯(lián)系方式 二維碼

服務熱線

18915418616

掃一掃,關注我們

主站蜘蛛池模板: 1300部真实小Y女视频合集 | 国产色精品久久人妻无码 | 亚洲成年男人的天堂网 | 吻嘴胸全身好爽床大全 | 婷婷午夜影院 | 朋友的娇妻好爽好烫嗯 | 欧美亚洲精品真实在线 | 亚洲午夜精品A片久久WWW解说 | 国产精品久久久久秋霞影视 | 人性本色联盟 | 日本久久高清视频 | 狠狠操伊人 | 我在厨房摸岳的乳HD在线观看 | 在线涩涩免费观看国产精品 | 超碰97超碰在线视频哦 | yellow日本动漫免费观看 | 亚洲黄色在线观看 | 毛片免费观看的视频在线 | 青娱乐视觉盛宴国产视频 | 最新无码专区在线视频 | 97国产精品人妻无码免费 | 国产露脸A片国语露对白 | 国产树林野战在线播放 | 新香蕉少妇视频网站 | 日韩亚洲人成在线 | 交换年轻夫妇HD中文字幕 | 超碰免费视频在线观看 | 人妻免费久久久久久久了 | 中文字幕完整高清版 | 亚洲精品午夜VA久久成人 | 成人在线免费视频播放 | 青青草干免费线观看 | 女教师跟黑人男朋友激情过后 | 猫咪av永久最新域名 | 亚洲国产成人精品无码区APP | 亚洲精品无码久久久久A片 亚洲精品无码国产爽快A片百度 | 久久这里只有精品国产精品99 | 伊伊人成亚洲综合人网 | 背着老婆爆操性感小姨子 | 中文字幕久久熟女人妻AV免费 | 国产精品JIZZ在线观看A片 |